Oligosaccharides, such as raffinose and stachyose in
legumes, are composed of 3-10 sugars. Polysaccharides are substances in
which multiple, often hundreds of monosaccharides molecules, are linked
together. The most abundant edible forms are the starches present in
grains, potatoes, etc., which are polymers of glucose. The two major forms
of these complex carbohydrates are amylose and amylopectin. In animals,
the storage form of carbohydrates is glycogen. Dextrins are fragments of
starch produced by dry heat, such as toasting.
Dietary fibers such as cellulose are polysaccharides in
which glucose or other monosaccharides are linked by bonds which cannot be
hydrolysed by the digestive enzymes produced in the intestine. Dietary
fiber, dextrins and some oligosaccharides are thus not digestible, except
through the action of enzymes produced by intestinal bacteria. Undigested
dietary fiber passes to the large bowel where it is fermented by bacteria
to yield lactic acid and the short-chain fatty acids acetic, propionic and
butyric acid. Humans derive measurable amounts of energy from the
metabolism of these products of bacterial fermentation. This process is
very active in herbivores which can thereby derive most of their energy
from cellulose. Other carbohydrate-related compounds include polyols (i.e.,
sugar alcohols such as sorbitol and xylitol) and organic acids, such as
ascorbic acid (i.e., vitamin C), citric acid and malic acid. Although
monosaccharides yield slightly less energy than starches (3.7 vs. 4.2
kilocalories per g), the energy value of dietary carbohydrates is
generally considered to be an even 4 kilocalories per gram.
Deficiency: There is no absolute
requirement for dietary carbohydrate, although the brain, the red blood
cells and some cells in the kidney use glucose as a preferred source of
energy. The liver has a considerable capacity to synthesize glucose from
amino acids (from dietary and body protein) and glycerol, released from
lipid hydrolysis. When intake of dietary sugars and starch is low or
lacking, stored fat (triacyglyceride) is mobilized, providing fatty acids
to sustain energy generation in the body. A carbohydrate-free diet is
associated with increased protein breakdown and ketone body formation in
the liver, which may produce dehydration and loss of cations, though not
to the same dangerous extent as in diabetic ketoacidosis. Starvation
ketosis is greatly attenuated by daily intakes of as little as 50-100 g of
carbohydrate.
Diet recommendations: No formal diet
recommendation for carbohydrates exists as intakes are adequate in US
diets, though consumption of some 25 grams of dietary fiber (i.e.
undigestible polysaccharides) is recommended. The Daily Value for
carbohydrates used in nutritional labeling is 60% of total calories, or
300 g/day for a 2,000 Calorie diet. In 1985, the US average carbohydrate
intake was 177 g in women and 287 g in men. Approximately 23% came from
fruits and vegetables and 41% was from grain products. About half of the
carbohydrate intake was in the form of mono- and disaccharides and the
reminder as complex carbohydrates.
Food sources: Monosaccharides such as
glucose and fructose are found in fruits and honey. Sucrose (glucose
linked to fructose), or table sugar (produced from sugar cane or sugar
beets) is the most commonly consumed disaccharide, found also in molasses,
maple syrup and some fruits. Maltose (two glucose units) is a component of
sprouting grains, malted cereals and syrups. By converting the glucose in
corn syrups into fructose, isosyrups with increased sweetening power are
produced which are used instead of cane sugar, notably in confectionary
items and soft drinks. Lactose (a dissacharide of glucose and galactose)
is the sugar in milk. Amylose is the dominant starch in wheat and rice.
Amylopectin is found in corn, potatoes and tapioca.
Resistant starches are starches which are poorly
digested in the human gastrointestinal tract, either because the starch is
in granular form (e.g., uncooked) and therefore resistant to digestive
enzymes, or in the form of retrograded amylose, which may form after
cooling starch that has been gelatinized by moist heating. Up to 7-10% of
starch from wheat, oats and potatoes and 20% from baked beans can pass
through to the colon. Resistant starches which reach the colon are
fermented there by the microflora and converted into short-chain fatty
acids, a process which also yields small amounts of methane gas and
hydrogen.
Recent research: Conversion of
carbohydrate into fat allows animals to build up fat reserves even when
their feed contains very little fat. It has therefore long been believed
that excess carbohydrate can readily be converted into stored body fat.
However, it is now well established that in man, fat synthesis is
essentially negligible under conditions of unrestricted access to food. On
another front, it has been shown recently that hyperactivity in children
is not associated with sugar intake. Of continued major interest are
studies on the beneficial effect of consuming more complex carbohydrates
which have a relatively low glycemic index (i.e., they cause a less abrupt
increase in blood glucose levels after meals) instead of the more rapidly
absorbed sugars and starches. This is particularly important for
individuals affected by insulin-dependent, as well as non-insulin
dependent, diabetes mellitus and because complex carbohydrates tend to
exert favorable effects on blood lipid levels in subjects at risk for
cardiovascular disease. In addition there is continuing research into the
role of non-starch polysaccharides (fiber) in the prevention of colonic
cancer.
Toxicity: Ingestion of even large
amounts of carbohydrates has no adverse effects, except that
lactose-containing milk products can lead to diarrhea in lactase-deficient
populations. In individuals affected by certain inherited
carbohydrate-metabolizing enzyme deficiencies, carbohydrate intake may
have to be carefully controlled to avoid possibly severe adverse reactions.
For further information:
Levin, R. J. (1998) In: Modern Nutrition in Health and
Disease (Shils, M. E., Olson, J. A., Shike, M. & Ross, A. C., eds.), 9th
ed., pp. 49-66. Williams & Wilkins, Baltimore, MD.
National Research Council. (1989) Diet and Health.
Implications for Reducing Chronic Disease Risk. National Academy Press,
Washington, DC
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