English

L

Carlo

Severini

Unit of Vector-borne Diseases and International Health, Department of Infectious, Parasitic and Immunomediated Diseases Istituto Superiore di Sanità, Viale Regina Elena 299     

00161 Rome   

 ITALY

Tel.: (+39.06) 49902303

Fax: (+39.06) 49903561

E-mail: severini@iss.it

Studi e formazione:

1982: Biology degree at the Department of Human and Animal Biology, University “La Sapienza” of Rome, Italy

1985: PhD in Evolutionary Biology at the Department of Human and Animal Biology, University “La Sapienza” of Rome, Italy;

1990: Master in Medical Entomology, Institut Pasteur, Paris

1991: WHO Certificate in Malaria and Planning Malaria Control (Thailand/Italy)

Incarichi, attività didattica 

1986-1988: Consultant, Directorate General for Development Cooperation, Italian Ministry of Foreign Affairs, Cooperative Malaria Control Project in Burkina Faso (Africa)

1988-1990: Head of a Cooperative Malaria Control Project in Madagascar (Africa), Directorate General for Development Cooperation, Italian Ministry of Foreign Affairs.

1991-to present: Researcher scientist, Unit of Vector-borne Diseases and International Health, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

2000 - 2005 Scientific co-ordinator of the project supported by European Commission, entitled 

“Resurgence of Plasmodium vivax Malaria in the Newly Independent States: Development of Innovative Tools for Monitoring Parasite Populations Spreading, to Potentiate Surveillance and Control of Malaria Outbreaks” (Copernicus-2 RDT Project Contract n° ICA2-CT-2000-10046, acronym VIVAXNIS)

Sintesi delle attività

Current research interest: Biochemical and molecular investigation in Medical Entomology and Protozoology

Identification and characterization of gene/protein associated with parasites-vectors interactions

Molecular diagnosis and genotyping of human malaria plasmodia

Molecular basis of drug resistance in Plasmodium falciparum and Plasmodium vivax

Pubblicazioni recenti selezionate

  1. 2008, Menegon M, Sannella AR, Majori G, Severini C. Detection of novel point mutations in the Plasmodium falciparum ATPase6 candidate gene for resistance to artemisinins Parasitology International, 57: 233-235

  2. 2008, Torcia MG, Santarlasci V, Cosmi L, Clemente A, Maggi L, Mangano VD, Verra F, Bancone G, Nebie I, Sirima BS, Liotta F, Frosali F, Angeli R, Severini C, Sannella AR, Bonini P, Lucibello M, Maggi E, Garaci E, Coluzzi M, Cozzolino F, Annunziato F, Romagnani S, Modiano D. Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proceedings of the National Academy of Sciences of the United States of America, 105: 646-51

  3. 2008, Sannella AR, Casini A, Gabbiani C, Messori L, Bilia AR, Vincieri FF, Majori G, Severini C.  New Uses for Old Drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: mechanistic and pharmacological implications. FEBS Letters, 582: 844-847

  4. 2007, Sannella AR, Messori L, Casini A, Vincieri F, Bilia AR, Majori G, Severini C. Antimalarial properties of green tea. Biochemical and biophysical research communications, 353:177-181.

  5. 2006, Severini C, Menegon M, Sannella AR, Paglia MG, Narciso P, Matteelli A, Gulletta M, Caramello P, Canta F, Xayavong MV, Moura INS, Pieniazek NJ, Taramelli D, Majori G. Prevalence of pfcrt point mutations and level of chloroquine resistance in plasmodium falciparum isolates from Africa. Infection, Genetics and Evolution, 6: 262-268.