Guide of PROTEIN DESIGN
Hecht Lab Research
Research paper covering work on amyloid proteins aims to understand how protein
misfolding and aggregation can cause human disease.
Hecht Research in my group is focused in two areas: (i ) design and construction of novel proteins; and (ii) probing the sequence determinants of amyloid formation
In our work on protein design, we have pioneered an approach that goes beyond the residue-by-residue design of individual amino acid sequences, and have developed strategies that enable construction of large libraries of de novo proteins
Our designed libraries include alpha-helical proteins, well-ordered and stable structures, cofactor-binding proteins, functionally active enzymes, amyloid -like structures, monomeric betasheet proteins, and self-assembled biomaterials
Designed Combinatorial Libraries of De Novo Proteins Constructing proteins de novo is ultimately about choosing amino acid sequences. The number of possible sequences from which to choose is enormous. Even for a relatively small protein, we cannot sample all possibilities. For example, for a chain of 100 residues composed of the 20 naturally occurring amino acids, there are 20 100 possibilities
This number is so large that a collection containing one molecule of each sequence would fill a volume larger than Avogadro's number of universes. Clearly, it is not practical to explore sequence space by designing and characterizing individual proteins one-by-one
iHOP - Information Hyperlinked over Proteins
Uses the network of genes and proteins as a natural way of accessing the millions
of biomedical abstracts in PubMed.
Protein Engineering Design and Selection
Publishes full-length original research papers which advance understanding of
the structural and biochemical basis of protein function.
Protein Engineering, Design and Selection PEDS Read This Journal In January 2004, the journal Protein Engineering was relaunched as Protein Engineering, Design and Selection , or PEDS
PEDS publishes research papers and review articles relevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for understanding fundamental properties of activity, stability, folding, misfolding and disease
Technology for MHC epitope removal, glycosylation to optimize pharmacokinetics,
masking immune recognition sites and engineering monoclonal antibodies.
Xencor Creating better antibody and protein therapeutic candidates through protein design
News PRESS RELEASE 9.11.2006: 10.18.2006 10.19.2006: Proteins by Design Among the most innovative new drugs on the market, antibody and protein biotherapeutics are changing the way physicians treat cancer, inflammation, and autoimmune disease
Our unique Protein Design Automation® suite of technologies allows us to systematically shape the clinical performance of protein-based drug leads to produce new drug candidates for development and commercialization by ourselves and by major life science and pharmaceutical partners
info: PROTEIN DESIGN
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The Protein Society: www.proteinsociety.org
19th Annual Symposium entitled 'The Integration of the Cellular Protein Machinery:
Complexes to Networks'. Held for five days in Boston, Massachusetts.
Ben Cravatt (The Scripps Research Institute), have put together an exceptional program, which will include more than 50 invited speakers and sessions including single molecule studies; dynamic post-translational modifications-beyond phosphorylation; protein folding; biochemistry and structure of ion channels; protein quality control; targeted proteomics; protein misfolding; structure and mechanism of formation; receptors and signaling; macro-molecular machines; dynamics in protein function; protein-protein interactions at the synapse; protein design; and in vivo imaging/biosensors
Protein & Peptide Science Group
Special interest section of the Royal Society of Chemistry, with contacts in
Belfast and London.
The interests of the Group have developed in recent years to cover: Protein structure determination, structure prediction, molecular modeling and dynamics, Protein separation and characterization, Protein biosynthesis, Protein expression, modification and targeting, combinatorial synthesis, Protein design and engineering, drug-Protein and Protein-Protein interactions and Protein structure-function
CBS Prediction Servers
Offers more than 30 online services for DNA and protein bioinformatics analysis.
Design of oligonucleotides for DNA microarrays
Food Product Design: The Beef Behind Meat Substitutes
Article explores the growing popularity of vegetarian "meats."
| Navigation The Beef Behind Meat Substitutes July 1995 -- Design Elements By: Lynn Kuntz Associate Editor* *(Editor since August 1996) H as meatless gone mainstream? Instead of turning up their noses at soy burgers, college students demand them
There are many reasons that have little to do with ethics or culture or religion.' Designing meat substitutes involves countless options: marketing, nutritional and, of course, technical
We think of a food product designed to replace meat
Meat alternatives consist of vegetable products designed to function like meat but organoleptically have little in common with it, often taking the form of what is colloquially called a 'veggie burger.' 'Some vegetarians don't want their products to taste like meat, ' says Gillette
They just want something that tastes good that is a protein source.' With a meatless entree, unless it uses some sort of meat analog as an ingredient, the design issues mirror those seen in traditional processed food products
The meat analog designer has the added burden of trying to create a product that passes for something it is not
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ISCID - International Society for Complexity Information and Design
ISCID is a cross-disciplinary professional society that provides a forum for
formulating, testing, and disseminating research on complex systems from an ... The International Society for Complexity, Information, and Design (ISCID) is a cross-disciplinary professional society that investigates complex systems apart from external programmatic constraints like materialism, naturalism, or reductionism
Its aim is to pursue the theoretical development, empirical application, and philosophical implications of information- and design-theoretic concepts for
They posit that not only can SNPs therefore be used to infer locally proximate deletions, but that both are responsible for variation in genetic phenotypes... Researchers at Duke University have proposed that a unified theory of physics will ultimately enable apparent common design features in the movement systems of diverse organisms and species to be a consequence of biological systems responding to environmental demands according to the same spatio-temporal dynamical rules or &‘flow&’... ISCID is pleased to announce the latest issue of
A variety of topics are addressed, including (1) computer simulations of Darwinian evolution , (2) irreducible complexity and (3) the application of intelligent design ... The 2005 International Conference on Natural Computation will feature the most up-to-date research results in computational algorithms inspired from nature , including biological, ecological, and physical systems... An enormous team of Chinese researchers have produced an improved map of the rice genome, and have proposed that new species and new functions in rice arose evolutionarily on the basis of a mutation-duplication mechanism whereby the genome &‘tests&’ mutations for efficacy ... A team of cognitive researchers investigating the bottlenecks in mental response to complex tasks proposes a stochastic model of cumulative evidence for modeling response times and processing ... IEEE Conference on Computational Complexity : June 12th - 15th, 2005, San Jose, California..
The Protein Crystallography Information Portal - index
Focused news, events, interviews, suppliers information and jobs related to
The report STRUCTURE-GUIDED DRUG DESIGN goes beyond the concept of structure-based drug design and its limited application to targets with a known 3D structure
STRUCTURE-GUIDED DRUG DESIGN has a broader remit and argues for the overriding importance of structure for the whole of the drug discovery process, from indication selection to market entry and beyond
Jay Ponder Lab Home Page
Graphical user interface to suites of molecular modeling tools, providing an
integrated environment for engineering applications. Contacts for the group at ...
Allows the user to redesign a portion of a known structure using a library of side chain rotamers
The PROPAK algorithm was one of the first attempts to attack this general protein design problem
TINKER Molecular Modeling Package
Complete and general package for molecular mechanics and dynamics, with some
special features for biopolymers.
TINKER Home Page TINKER - Software Tools for Molecular Design Current Major Version: TINKER 4.2 Major Release Date: June 2004 Last Minor Revision: September 8, 2004 Introduction The TINKER molecular modeling software is a complete and general package for molecular mechanics and dynamics, with some special features for biopolymers
PROTEIN DESIGN ?
Folding simulations for fusion peptides, proteins and RNA with aim of predicting
structure from genome by research at Stanford University, California.
A Guide to Structure Prediction
Just a little time to analyse a sequence can possibly save time and money by aiding experimental design
Nevertheless, the other sections of the flowchart can provide useful insights into protein structure and function, and provide information that can aid experimental design
Combinatorics, theory of computation and algorithms.
Academics Current PhD students: Current post-docs: (joint with Carnegie Mellon University) Completed PhD students: Dion Harmon Thesis: (2006) (cosupervised with ) Thesis: (2006) (now a post-doc at MIT and Carnegie Mellon University) Thesis: (2005) (cosupervised with , now a post-doc at ) Thesis: (2005) (now an Assistant Professor at ) Thesis: (2005) Academic 'parents' (PhD co-advisors): and Undergraduate advisor since September 2002 Teaching at MIT: , Introduction to Algorithms (, including , also on ; ; ; and including , also on ) , Advanced Data Structures (, ) (IAP 2005) , Folding and Unfolding in Computational Geometry (Fall 2004) , Form-Finding and Structural Optimization: Gaudi Workshop (Fall 2004) Formerly , 3-D Design Tools for Equilibrium: Exploring Gaudi's World (Spring 2004) (IAP 2004) , Advanced Algorithms (Fall 2003) Refer to my CV for committees etc
BSP :: Protein & Peptide Letters Home Page
Publishes on all aspects of protein and peptide research, including structural
studies, recombinant expression, function, synthesis, enzymology, immunology, ...
Journals & Books: Access Bentham Online: Marketing Opportunities: Authors: Protein & Peptide Letters ISSN: 0929-8665 - Volume 13, 10 Issues, 2006 Aims & Scope Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc
Protein & Peptide Letters will focus on: Structure Studies Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis Indexed in MEDLINE, Chemical Abstracts, CABS, ISI Biochemistry, BIOSIS, BBCI, EMBASE, BIOBASE, Biomed Link, Science Citation Index, Biophysics Citation Index You may also be interested in:
Human Resource - Biotechnology Industry Information. Employment ...
Lists links to company webpages within the industry along with descriptions of
- Supporting innovative biotechnology: basic research, drug design, drug screening and chemical synthesis
- Develops products and services designed to measure and use information in pharmacogenetics and drug discovery
- Transgenic plants design and testing
- Targets bioseparation and medical applications with its platform technologies, exploiting its proprietary synthetic ligands designed to effect very specific interactions with proteins
Protein Design Labs (PDL, the Company) develops humanized and human monoclonal antibodies to prevent and treat various disease conditions and novel gene-based small molecule compounds to treat microbial infections
- A biopharmaceutical company dedicated to the discovery, design, and development of novel pharmaceutical compounds to treat vascular disease
Our patented naked DNA technology and proprietary lipids are designed to deliver genes into cells in the body
F. Edward Boas -- Home page
His resume, school experience and projects.
The Fourth Foresight Conference on Molecular Nanotechnology. Palo Alto, California.
computational models, system design issues) natural molecular machines (e.g
BioMed Central | BMC Bioinformatics
BMC Bioinformatics (ISSN 1471-2105) is a fully peer reviewed online journal
publishing research articles with open access for all. BMC Bioinformatics covers all ...