About of DIGITAL MICROFLUIDICS
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. Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS.. An in-line sample purification method for MALDI-MS, which relies on the electrowetting-on-dielectric (EWOD)-based technique for digital microfluidics, is reported.
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. Digital microfluidics using soft lithography.
Advanced Liquid Logic, Inc.
. Nanoliter Lab-on-a-Chip Video of droplet transport on a digital microfluidic chip (shown at actual 1X speed) Digital Microfluidics is a lab-on-a-chip approach based upon direct programmable micromanipulation of nanoliter-sized droplets using electrical fields.. Digital microfluidics enables complex, multi-step liquid handling protocols to be flexibly and scalably implemented in a nanoliter volume format.. Graphical representation of the digital microfluidics platform.
digital microfluidics: Information From Answers.com
On this page: digital microfluidics digital microfluidics Digital microfluidics is an alternative technology for lab-on-a-chip systems based upon micromanipulation of discrete droplets.. And in contrast to continuous-flow, digital microfluidics works much the same way as traditional bench-top protocols, only with much smaller volumes and much higher automation.. It may not have been reviewed by professional editors (see ) Mentioned In digital microfluidics is mentioned in the following topics: Copyrights: Wikipedia information about digital microfluidics This article is licensed under the .
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High-Throughput Proteomics Using Digital Microfluidics
Text Size: High-Throughput Proteomics Using Digital Microfluidics Collaborators: , and Joe Loo CNSI/UCLA Collaboration between CNSI and UCLA Proteomics and Mass Spectrometry Center Proteomics is the profiling of the entire constellation of proteins present in a cell or organism at a particular point in time.. Droplet-based ("digital") microfluidics are being developed to prepare and process samples for MALDI-MS, as well as other bioanalytical assays.. The digital microfluidics device thus provides a unique and versatile platform for method development as well as sample analysis.
People
. Wheeler, AR Moon, H Bird, CA Loo, RR Kim, CJ Loo, JA Garrell, RL Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS... Wheeler, AR Moon, H Bird, CA Loo, RR Kim, CJ Loo, JA Garrell, RL Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS... Electrowetting-based microfluidics for analysis of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry.
Coordinating Multiple Droplets in Planar Array Digital Microfluidics Systems
Coordinating Multiple Droplets in Planar Array Digital Microfluidics Systems Eric Griffith and Srinivas Akella Rensselaer Polytechnic Institute Based on figure from Duke University The Components Street Connector Intersection Source Sink Work Area Sample Animations (if you don't want to download the DivX codec).. Goldberg ``Performance Characterization of a Reconfigurable Planar Array Digital Microfluidic System, '' IEEE Transactions on Computer-Aided Design of Integrated Circuits And Systems , Special issue on Design Automation Methods and Tools for Microfluidics-Based Biochips, Vol.
View Grant Details
| · · · · · · Details of Grant EPSRC Reference: EP/D003091/1 Title: Optically Controlled Digital Microfluidics: Chemistry in Aerosol and Surface-Microdroplet Arrays Principal Investigator: Other Investigators: Recognised Researchers: Project Partner: Department: Physics and Astronomy Organisation: University of St Andrews Abstract: Performing a chemical analysis of a small sample volume is challenging.
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Geometry of liquid interfaces Digital Microfluidics Background and Motivation It has been realized in recent years that the classical concept of microfluidics, i.e., the confinement of the flow of single phase liquids to networks of narrow channels, has some fundamental drawbacks.. Combined with a means to pump the emulsion and analysis (e.g., optical) and manipulation tools, controlling these systems may open up new routes in compartmented microfluidics.. This may be called digital microfluidics, and is well suited for extensive applications in combinatorial chemistry, DNA sequencing, drug screening, and any other field where similar chemical reactions have to be induced with a large number of different molecules involved.. We term this "digital microfluidics" because well defined quantities are used rather than continuous flow.. Our aim is to run this kind of (digital) microfluidics with droplet sizes from 1 to some 10 microns.
Faculty Profile
. Two paradigms have emerged for lab-on-a-chip: channel and digital microfluidics.. Channel microfluidics relies on enclosed, interconnecting, micron-dimension channels.. Digital microfluidics enables transport of discrete droplets of fluid across the surface of an array of electrodes.. Channel and digital microfluidics offer unique and in many cases complementary advantages.. We are developing hybrid methods that rely on the unique advantages of channel and digital microfluidics for high throughput bioanalytical applications.. We are developing instruments and methods, based on channel and digital microfluidics for integrated processing and MS-based analysis of proteins in crude biofluids (saliva, serum, cell lysate, etc.).. We are developing instruments and methods based on channel and digital microfluidics capable of conducting high throughput phenotypic screening on disposable devices with no moving parts and minimal reagent use.. "Electrowetting-Based Microfluidics for Analysis of Peptides and Proteins by Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS)" Anal.
LCMD :: Research -> Digital Microfluidics
Digital Microfluidics Bioanalysis in microcircuits Microfluidics should enable the miniaturization of chemical or biochemical analysis, in order to assay a sample in small volumes with high-throughput.
LCMD :: Home > Job Offers
Work at the LCMD Job offers PhD offer (starting September 2006) The aim is to apply the principle of Digital Microfluidics for cell-based high-throughput screening (HTS).. In Digital Microfluidics Systems (DMS) the individual assays are compartmentalised in microdroplet microreactors.. In Digital Microfluidics Systems (DMS), aqueous microdroplet reactors which are carried in a fluorocarbon oil act as independant microreactors, and therefore as aimed in this project, also as minimal artificial cells.
DIGITAL MICROFLUIDICS ?
Digital microfluidics using soft lithography
(DOI: 10.1039/b510127a)
Lab Chip , 2006, 6, (1), 96-104 DOI: 10.1039/b510127a Paper Digital microfluidics using soft lithography John Paul Urbanski a , William Thies b , Christopher Rhodes a , Saman Amarasinghe b and Todd Thorsen * a Hatsopoulos Microfluids Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA.. The driving force behind the lab-on-a-chip movement is microfluidics, which enables storage, transport, and manipulation of fluids at the picoliter scale.. Microfluidics provides for the experimental sciences what the integrated circuit provided for electronics more than 50 years ago: the ability to integrate diverse micro-scale components in a unified fabrication process.. At the device level, microfluidics is becoming a mature technology.. A high-level programming library for microfluidics has been developed which allows the experimentalist to specify general operations ( e.g.. In this research, a portable system for microfluidics programming has been developed based on a Java library.
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